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慢性透析患者における貧血改善の心機能と運動能力に及ぼす影響について

フォーマット:
論文(リポジトリ)
責任表示:
筒井, 牧子 ; Tsutsui, Makiko
出版情報:
新潟医学会, 1990-03
掲載情報:
新潟医学会雑誌
ISSN:
0029-0440
巻:
104
通号:
3
開始ページ:
206
終了ページ:
213
バージョン:
publisher
概要:
We examined physical exercise capacity and hemodynamics by the use of a treadmill stress test before and after the administration of recombinant human erythropoetin (rEPO) in chronic dialysis patients. The subjects are 39 cases, 19 males an d 20 females, on chronic hemodyalysis who had renal anemia. The range of age was 15 to 57 years and the average was 37.4 years. The multistage treadmill test were carried out before the administration of rEPO and at the times when the hematcrit(Ht.) rose by 5-6%, by 10-12%, and after 2-3 months maintaining the rise of Ht. by 10-12%. The echocardiogram prior to the exercise test was carried out. Results: Ht. value and hemoglobin level improved remarkably. When Ht. rose by 10-12%, the following parameters decreased significantly, Left ventricular diastolic dimension (p<0.01), left ventricular systric dimension (p<0.05), left ventricular enddiastric volume (p<0.01), left ventricular endsystoric volume (p<0.01), cardiac output (p<0.001). Ejection fraction increased significantly (p<0.05). Blood pressure at rest showed significant rise in the diastolic pressure only when Ht. increase by 10-12% (p<0.05). Although the heart rate at rest showed a significantly fall (p<0.05), maximal heart rate on exercise and the maximal pressure rate product did not show any significant change. VO_2 max showed a significant increase (p<0.001), and it remained at a higher level thereafter. The exercise time prolonged significantly (p<0.001). The remarkable improvement of anemia induced by rEPO caused the improvement of physical activity, VO_2 max and cardiac function as well as the reduction of anemic symptomes. 続きを見る
著者名:
URL:
http://hdl.handle.net/10191/33740

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